ChloroquineV1, France, Analysis, bibRecord, 000396

Airway obstruction in bronchial sarcoidosis: Outcome With treatment

Identifieur interne : 000396 ( France/Analysis ); précédent : 000395; suivant : 000397

Airway obstruction in bronchial sarcoidosis: Outcome With treatment

Auteurs : F. Lavergne [France] ; C. Clerici [France] ; D. Sadoun [France] ; M. Brauner [France] ; J.-P. Battesti [France] ; D. Valeyre [France]

Source :

Chest [ 0012-3692 ] ; 1999.

RBID : Pascal:99-0557896

Descripteurs français

Pascal (Inist)
- Sarcoïdose, Granulome, Paroi, Bronche, Obstruction, Voie respiratoire, Complication, Homme, Traitement, Chimiothérapie, Fonction respiratoire, Evolution, Efficacité traitement, Exploration, Corticostéroïde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bronchus, Chemotherapy, Complication, Corticosteroid, Evolution, Exploration, Granuloma, Human, Lung function, Obstruction, Respiratory tract, Sarcoidosis, Treatment, Treatment efficiency, Wall.

Abstract

Study objective: Airway obstruction (AO) in sarcoidosis is reported to be associated with respiratory symptoms, increased morbidity, and an increased mortality risk. Because AO in sarcoidosis may result from several causes, the therapeutic benefit of corticosteroids is difficult to determine. The aim of this study was to evaluate the therapeutic response of AO attributable to sarcoid granulomas in the bronchial wall. Patients: We selected 11 patients who had sarcoidosis with AO (defined as FEV₁/vital capacity [VC] < 70%) associated with sarcoid granulomas on an endobronchial biopsy. Exclusion criteria were history of asthma, smoker or exsmoker, stage 4 disease, evidence of extrinsic compression by enlarged lymph nodes, and localized endobronchial stenosis seen during fiberoptic bronchoscopy. Interventions: We compared the results of pulmonary unction tests an clinical, radiologic, an biological findings at baseline with those obtained at the time of the last pulmonary function tests available, between the sixth and 12th months of treatment. Eight patients took oral corticosteroids (20 to 60 mg/d initially), one received IV methylprednisolone pulses, another took oral hydroxychloroquine, and the last one received IM methotrexate. Measurements and results: With treatment, FEV₁ and FEV₁/VC significantly improved in eight patients (72%), normalized in four patients, and was unchanged in the remaining three patients. The mean FEV₁ increased from 60.8 ± 10.8% to 76 ± 13.7% of the predicted value (p < 0.02). VC did not change significantly. FEV₁/VC increased from 76.1 ± 6.4% to 87.6 ± 10.7% of the predicted value (p < 0.01). Dyspnea on exertion and other clinical findings were attenuated in 10 patients; the chest radiograph improved in 9 patients, and normalized in 5 patients. The mean serum angiotensin-converting enzyme level decreased from 112 ± 48 to 58 ± 40 IU/mL (p < 0.05), and normalized in four patients. Conclusion: The present study indicates that AO caused by sarcoid granulomas in the bronchial wall can be either partially or completely reversed by treatment with a concomitant attenuation of pulmonary symptoms.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000067
to stream PascalFrancis, to step Curation: 000103
to stream PascalFrancis, to step Checkpoint: 000072
to stream Main, to step Merge: 002752
to stream Main, to step Curation: 002714
to stream Main, to step Exploration: 002714
to stream France, to step Extraction: 000396

Links to Exploration step

Pascal:99-0557896

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Airway obstruction in bronchial sarcoidosis: Outcome With treatment</title>
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<author><name sortKey="Brauner, M" sort="Brauner, M" uniqKey="Brauner M" first="M." last="Brauner">M. Brauner</name>
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<author><name sortKey="Battesti, J P" sort="Battesti, J P" uniqKey="Battesti J" first="J.-P." last="Battesti">J.-P. Battesti</name>
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</author>
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<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Service de Pneumologie, Hôpital Avicenne (Assistance Publique-Hôpitaux de Paris), UFR Bobigny</s1>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bronchus</term>
<term>Chemotherapy</term>
<term>Complication</term>
<term>Corticosteroid</term>
<term>Evolution</term>
<term>Exploration</term>
<term>Granuloma</term>
<term>Human</term>
<term>Lung function</term>
<term>Obstruction</term>
<term>Respiratory tract</term>
<term>Sarcoidosis</term>
<term>Treatment</term>
<term>Treatment efficiency</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Sarcoïdose</term>
<term>Granulome</term>
<term>Paroi</term>
<term>Bronche</term>
<term>Obstruction</term>
<term>Voie respiratoire</term>
<term>Complication</term>
<term>Homme</term>
<term>Traitement</term>
<term>Chimiothérapie</term>
<term>Fonction respiratoire</term>
<term>Evolution</term>
<term>Efficacité traitement</term>
<term>Exploration</term>
<term>Corticostéroïde</term>
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<front><div type="abstract" xml:lang="en">Study objective: Airway obstruction (AO) in sarcoidosis is reported to be associated with respiratory symptoms, increased morbidity, and an increased mortality risk. Because AO in sarcoidosis may result from several causes, the therapeutic benefit of corticosteroids is difficult to determine. The aim of this study was to evaluate the therapeutic response of AO attributable to sarcoid granulomas in the bronchial wall. Patients: We selected 11 patients who had sarcoidosis with AO (defined as FEV<sub>1</sub>
/vital capacity [VC] < 70%) associated with sarcoid granulomas on an endobronchial biopsy. Exclusion criteria were history of asthma, smoker or exsmoker, stage 4 disease, evidence of extrinsic compression by enlarged lymph nodes, and localized endobronchial stenosis seen during fiberoptic bronchoscopy. Interventions: We compared the results of pulmonary unction tests an clinical, radiologic, an biological findings at baseline with those obtained at the time of the last pulmonary function tests available, between the sixth and 12th months of treatment. Eight patients took oral corticosteroids (20 to 60 mg/d initially), one received IV methylprednisolone pulses, another took oral hydroxychloroquine, and the last one received IM methotrexate. Measurements and results: With treatment, FEV<sub>1</sub>
 and FEV<sub>1</sub>
/VC significantly improved in eight patients (72%), normalized in four patients, and was unchanged in the remaining three patients. The mean FEV<sub>1</sub>
 increased from 60.8 ± 10.8% to 76 ± 13.7% of the predicted value (p < 0.02). VC did not change significantly. FEV<sub>1</sub>
/VC increased from 76.1 ± 6.4% to 87.6 ± 10.7% of the predicted value (p < 0.01). Dyspnea on exertion and other clinical findings were attenuated in 10 patients; the chest radiograph improved in 9 patients, and normalized in 5 patients. The mean serum angiotensin-converting enzyme level decreased from 112 ± 48 to 58 ± 40 IU/mL (p < 0.05), and normalized in four patients. Conclusion: The present study indicates that AO caused by sarcoid granulomas in the bronchial wall can be either partially or completely reversed by treatment with a concomitant attenuation of pulmonary symptoms.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Bobigny</li>
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<tree><country name="France"><region name="Île-de-France"><name sortKey="Lavergne, F" sort="Lavergne, F" uniqKey="Lavergne F" first="F." last="Lavergne">F. Lavergne</name>
</region>
<name sortKey="Battesti, J P" sort="Battesti, J P" uniqKey="Battesti J" first="J.-P." last="Battesti">J.-P. Battesti</name>
<name sortKey="Brauner, M" sort="Brauner, M" uniqKey="Brauner M" first="M." last="Brauner">M. Brauner</name>
<name sortKey="Clerici, C" sort="Clerici, C" uniqKey="Clerici C" first="C." last="Clerici">C. Clerici</name>
<name sortKey="Sadoun, D" sort="Sadoun, D" uniqKey="Sadoun D" first="D." last="Sadoun">D. Sadoun</name>
<name sortKey="Valeyre, D" sort="Valeyre, D" uniqKey="Valeyre D" first="D." last="Valeyre">D. Valeyre</name>
</country>
</tree>
</affiliations>
</record>

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Airway obstruction in bronchial sarcoidosis: Outcome With treatment

Airway obstruction in bronchial sarcoidosis: Outcome With treatment

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri